Lab on a Chip Technology

Technologies developed by Klearia are based on microfluidics, especially lab-on-a-chips. Lab-on-a-chips are small devices for small samples monitoring. As example: usual and commercial lab-on-a-chips applications are pregnancy and glucose tests. Klearia doesn’t only manufacture microfluidic chips, Klearia extends use of microfluidics up to design and manufacturing of glass lab-on-a-chips. Our exclusive and patented technology lets us develop instrumentations on a chip and nanostructured structures. Biology, health, environment and agrofood are sectors able to be very interested in the development of microfluidic sensors allowing electrochemical detection.

Microfluidics: a technology with advanced capabilities

Microfluidics is a multidisciplinary field intersecting engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology, with practical applications to the design of systems in which low volumes of fluids are processed to achieve multiplexing, automation, and high-throughput screening. It deals with the behaviour, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale.

Microfluidic chips: tools for outstanding monitoring

A microfluidic chip is a pattern of microstructures engraved or molded. This micro-network defines the microfluidic chip. Due to the scale down, a microfluidic chip enables experiments with sample volume reduction and reagent consumptions and shorter time of experiments. The experiments scale down enables local concentration increase of any component.

 

Lab-on-a-chip: Level up of microfluidics

A lab-on-a-chip is a device that integrates one or several laboratory functions on a tiny single chip to achieve automation and high-throughput screening. Lab-on-a-chips deal with the handling of extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of Micro-electro-mechanical systems (MEMS) devices and often indicated by “Micro Total Analysis Systems” (µTAS) as well. Lab-on-a-chip is closely related to, and overlaps with, microfluidics which describes primarily the physics, the manipulation and study of minute amounts of fluids.

Klearia: benefits of glass at the service of monitoring

First of all, glass is the right choice if the application needs excellent mechanical stability combined with excellent flatness. Most applications using optical detection benefit from glass as a substrate material.

Moreover, glass is biocompatible, chemically inert, hydrophilic and allows efficient coatings. Its surface chemistries, superior optical transparency and high-pressure resistance make it the best choice for many applications. For more information about our capabilities, please click here.

Finally, Klearia overcomes a major technological limitation by bonding at a low temperature between 100°C and 300°C and succeed in integrating a wider range of materials and devices. Low temperature bonding (≤300°C) enables integration of more materials for embedded technologies. Thus, Klearia is capable, besides ITO, Pt, Au and Cu, to integrate termodegradable materials like carbon, nanostructured gold, etc. With our low temperature sealing technology, it is now possible to integrate multilayer materials with heterogeneous expansion coefficients, nanostructured materials, thermodegradable materials.